Getting from Amsterdam to Prague: Your options between the two cities

Even though they aren't in neighboring countries, Amsterdam and Prague are popular with a lot of the same travelers, so they get strung together on plenty of European trips. Assuming you aren't planning on hitchhiking (don't), you've got three real options, and all of them are worth considering.

A lot has changed on this route since this page was first written. SkyEurope, the budget airline that used to fly it twice a day, went bankrupt in 2009. The Eurolines bus is gone too, after FlixBus bought the business in 2019. The good news: a direct sleeper train is back.

Quick summary

The European Sleeper night train is the most fun, runs three nights a week and starts at 79.99 euros for a shared compartment. A daytime train via Berlin takes a little over 11 hours and starts at 46.99 euros. KLM and easyJet fly nonstop in under two hours. FlixBus is the cheapest and slowest.

Trains between Amsterdam and Prague

There are now two good ways to do this by rail.

The night train: European Sleeper

In March 2024 the Dutch-Belgian cooperative European Sleeper extended its Brussels-Amsterdam-Berlin night train to Dresden and Prague, bringing back a direct Amsterdam to Prague train for the first time in about ten years. Per the official timetable:

• Amsterdam to Prague: Monday, Wednesday and Friday nights. Leaves Amsterdam Centraal at 22:31, reaches Berlin Gesundbrunnen at 07:00 and Prague hlavní nádraží at 12:15.
• Prague to Amsterdam: Tuesday, Thursday and Sunday. Leaves Prague at 18:00 and arrives in Amsterdam Centraal at 06:43 the next morning.

The morning run along the Elbe valley between Dresden and Prague is the reward for a so-so night's sleep. Shared compartments start at 79.99 euros per person one way, and private compartments cost a lot more (from 279.99 euros as of 2026). Couchettes are simple bunks in a shared compartment, and there are women-only compartments if you want one. Book at europeansleeper.eu.

Timetables around track work aren't always reflected in the published schedule, and Seat61 reports that Amsterdam-Berlin trains are being diverted via Hamburg-Harburg from 2 October to 12 December 2026. If you're traveling in that window, check your times close to departure.

The day train, with a few hours in Berlin

You can also do it in a single day with one change in Berlin, and it's a nice excuse for a long lunch there. Seat61 lists departures from Amsterdam Centraal at 06:00 (arriving Prague 17:25), 08:00 (arriving Prague Holešovice 19:15) and 10:00 (arriving Prague 21:25). The Berlin to Prague leg runs down the Elbe valley too: sit on the left for the views.

Fares start at 46.99 euros in second class and 59.99 euros in first (as of 2026). Book at int.bahn.de, and it's worth comparing with Czech Railways at cd.cz, which sometimes sells the same trains for less.

Flights between Amsterdam and Prague

Since the ground options each take half a day or a night, this is one city pair where flying saves real time. KLM and easyJet are the two airlines flying nonstop, with about 24 flights a week between them as of September 2026 (FlightConnections). The flight itself is roughly 1 hour 25 minutes to 1 hour 40 minutes.

easyJet is usually the one to watch for low fares, while KLM has the better schedule and connections. Schiphol is a quick train ride from Centraal (see our Schiphol Airport guide), and Prague's airport is linked to the city by bus, so allow a couple of hours on top of the flight time either way.

Buses between Amsterdam and Prague

FlixBus now runs this route, with several departures a day including overnight buses. The fastest trips take about 12 hours 15 minutes, and when we checked in September 2026 fares started from about $36 (a little over 30 euros).

In Amsterdam, buses use stops at Sloterdijk, Schiphol Airport, Centraal Station and Bijlmer Arena, not Amstel Station as they used to. In Prague, most arrive at Florenc, the main bus station, though some use the main railway station and other terminals around the city. Check your stop when you book.

For the hardcore backpacker set, an overnight bus still saves a night in a hostel. Everyone else will probably be happier on the sleeper train, which isn't much more if you book early and lets you lie flat.

Making it part of a bigger trip

Berlin is the obvious stop in between: see our guide to getting from Amsterdam to Berlin. If Amsterdam and Prague are two stops on a longer trip, AirTreks, BootsnAll's sister company, has been building multi-stop and round-the-world tickets since 1987. A sample route that covers exactly this stretch: